PROFHILO®️ STRUCTURA – Bioremodeling and Adipose Tissue Restoration for Facial Volume Loss
Facial aging is not limited to the appearance of wrinkles and a loss of skin elasticity. During the aging process, changes also occur within the deep and superficial fat compartments of the face. The loss of volume and structural support in adipose (fat) tissue can lead to issues such as a sunken appearance in the cheeks, flattening of the midface, a loss of definition along the facial contour, and the downward displacement of tissues.
Profhilo®️ Structura is a new-generation, hyaluronic acid-based bioremodeling treatment designed to target the facial fat compartments that undergo changes with aging.
Unlike conventional dermal fillers, which primarily focus on adding volume to specific areas of the face, Profhilo®️ Structura aims to improve the structural support and integrity of the superficial fat tissue.
What is Profhilo®️ Structura?
Profhilo®️ Structura is an injectable medical product developed by IBSA. It utilizes the patented NAHYCO®️ Hybrid Technology and contains a combination of high- and low-molecular-weight hyaluronic acid.
Its 2 ml formulation contains a total of 90 mg of hyaluronic acid:
• 45 mg of high-molecular-weight hyaluronic acid (H-HA)
• 45 mg of low-molecular-weight hyaluronic acid (L-HA)
These hybrid cooperative complexes—created without the use of chemical cross-linking agents—give the product its unique rheological properties and ability to integrate seamlessly into the tissue.
How does Profhilo®️ Structura work?
A significant change associated with facial aging is the loss of volume and structural integrity within the superficial fat compartments. Profhilo®️ Structura specifically targets these areas of adipose (fat) tissue, aiming to improve tissue integration and provide structural support to the fat compartments.
Through the biological and physical properties of its formulation, it aims to:
• Address age-related changes in adipose tissue.
• Enhance structural support in the mid-face and lateral facial regions.
• Promote a more balanced appearance of facial contours.
• Improve the quality of the skin and subcutaneous tissues.
• Achieve a more natural and refreshed look for the face.
Where can Profhilo®️ Structura be applied?
The treatment is planned based on an assessment of the face’s anatomical structure and the condition of its fat compartments.
Specifically, the following areas may be included in the treatment plan, subject to a physician’s evaluation:
• The mid-face region.
• The lateral aspect of the cheeks.
• Appropriate fat compartments around the temples.
• The preauricular area (the area in front of the ears).
• Areas along the facial oval (jawline/lower face contour) where there is a loss of structural support.
Who is a suitable candidate for Profhilo®️ Structura?
• Individuals experiencing age-related loss of facial adipose tissue.
• Those noticing a sunken appearance or loss of volume in the cheek area.
• Individuals with reduced structural support in the mid-face.
• Those who have experienced a loss of definition along the facial oval.
• Individuals seeking a “bioremodeling” approach that differs from traditional dermal filler treatments.
Appropriate patient selection must be determined through a thorough assessment of facial anatomy and fat compartments.
How many sessions are required?
The manufacturer’s instructions for use generally recommend an initial protocol consisting of two sessions, spaced 30 days apart.
Depending on individual needs, maintenance sessions may be considered, typically spaced approximately four months apart. The frequency of treatment is determined by the physician based on the degree of aging and the patient’s anatomical characteristics.
What is the difference between Profhilo®️ Structura and classic Profhilo®️?
Although both products utilize NAHYCO®️ technology, they target different tissues and serve different purposes.
Profhilo®️: Primarily aims to support skin quality, hydration, and elasticity.
Profhilo®️ Structura: Specifically targets the superficial adipose (fat) tissue compartments—which undergo changes due to aging—with the goal of improving the face’s structural support and the integrity of its adipose tissue.
Consequently, Profhilo®️ Structura offers a treatment approach that differs from conventional skin hydration and bioremodeling procedures.
The difference between Profhilo®️ Structura and dermal fillers
The primary objective of classic hyaluronic acid-based dermal fillers is to add volume to specific anatomical areas and to define contours.
Profhilo®️ Structura, however, is not a cross-linked volumizing filler. Its goal is to integrate with the appropriate superficial adipose tissue compartments to improve structural changes associated with aging.
A more natural approach to facial rejuvenation
Successful facial rejuvenation is achieved not merely by eliminating wrinkles, but by preserving the face’s anatomical integrity and natural proportions.
By employing a bioremodeling approach that targets the facial adipose tissue—which changes throughout the aging process—Profhilo®️ Structura represents a new generation of medical aesthetic options designed to maintain the face’s natural structure while fostering a more balanced and refreshed appearance.
Every face ages in its own unique way. For this reason, the procedure should be planned on an individual basis, taking into account facial anatomy, the state of fat compartments, and the person’s expectations.